Jennifer Aniston is no stranger to romantic comedies, having starred in her fair share of them, such as "Picture Perfect," "The Object of My Affection," "The Breakup," and more (via IMDb). However, in 2001 after taking a meeting to discuss her playing the lead role of Sara in the film "Serendipity," the actress opted to pass on the movie. According to People Magazine, Aniston decided that she didn't want to do another romantic comedy at the time because she starred in a romantic comedy each week as Rachel Green on the hit series "Friends."
"I remember when she came in, she said, 'I do a romantic comedy once a week,' her being on Friends at the time, so she clearly had other things on her plate, and it was her decision not to do it," director Peter Chelsom said to People Magazine. "She had come to meet with me in good faith without an offer, but we definitely would have made her an offer if she wanted to make it."
The role ultimately went to Kate Beckinsale, who nailed the part. However, actresses such as Claire Forlani and Carla Gugino were also in consideration for the role (via People Magazine).
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